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Tatyana Dobreva, Ph.D. Thesis Defense

Monday, August 30, 2021
11:00am to 12:00pm
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Engineering tools to probe and manipulate the immune system at single-cell resolution
Tatyana Dobreva, Ph.D. Student, Department of Medical Engineering, California Institute of Technology,


My research focuses on developing experimental and computational tools to probe and manipulate cellular transcriptomes in the context of human health and disease. For probing cellular transcriptome states, I have leveraged single-cell RNA sequencing (scRNA-seq) to understand human immune variability, characterize cell-type specific biases of multiple viral variants within an animal, and assess temporal immune response in the brain to delivery of genetic cargo via an adeno-associated virus (AAV). In the context of manipulating cells, I have made progress on tools for exporting RNA extracellularly and engineering of a transcription factor for modulating macrophage state.

For more information, please contact Christine Garske by email at [email protected] or visit https://mede.caltech.edu/seminars/thesis.